![]() ![]() Heterogeneous by nature, PCOS involves a variety of signs and symptoms of ovulatory dysfunction and androgen excess. Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in females, affecting 10–15% of reproductive-age women worldwide 1. Accordingly, phenotype division may help physicians to predict adverse metabolic outcomes. In conclusion, the full-blown PCOS (O–H–P) phenotype has an increased risk of insulin resistance. Moreover, individuals with O–H–P phenotype (odds ratio 2.52, 95% confidence interval 1.02–6.24) had about two-fold increased risk of insulin resistance. In addition, the HOMA-IR index was found to be positively correlated with alanine transaminase and negatively correlated with diastolic blood pressure in normal weight PCOS women. Based on our results, the HOMA-IR index was positively correlated with diastolic blood pressure, free androgen index, and triglycerides levels and negatively correlated with sex hormone-binding globulin in overweight/obese PCOS women. A total of 125 PCOS patients aged 18–40 years were included in the present study. Then, the association between PCOS phenotypes and insulin resistance was investigated using logistic regression analysis. ![]() The correlation between the HOMA-IR and biometric, clinical, and biochemical variables was assessed in normal weight (BMI < 25) and overweight/obese (BMI ≥ 25) PCOS women. Participants were categorized into two groups according to the homeostasis model assessment index of insulin resistance (HOMA-IR) levels: < 3.46, and ≥ 3.46. PCOS patients were categorized into the four Rotterdam PCOS phenotypes according to the presence of at least two criteria of oligomenorrhea/anovulation (O), hyperandrogenism (H), and polycystic ovary morphology (P): O–H–P, H–P, O–H, and O–P. In this cross-sectional secondary analysis, we combined the baseline data from two separate randomized controlled trials (RCTs) in women diagnosed with PCOS. The second aim was to compare the clinico-biochemical profiles of the various PCOS phenotypes. ![]() This study aimed to compare clinical, metabolic, and hormonal characteristics of PCOS women with and without insulin resistance. Polycystic ovary syndrome (PCOS) has significant metabolic sequelae linked to insulin resistance. ![]()
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